Mariana Derderián was born in Caracas, Venezuela, daughter of Armenian parents. She arrived in Chile in the early 1990 with her older sister. She accomplished her secondary studies in San Pedro Nolasco school in the community of Las Condes, and then was accepted at the Universidad Mayor to study business engineering. During her third year of study, Mariana found out that her professional vocation was the theatre and decided to take evening workshop, first in the municipalities of Vitacura and Las Condes, and then in the Academy of Fernando González.

At the end of 2004, Derderián and a classmate showed up at an audition at Canal 13, where she got selected to participate in the TV series Brujas where she interpreted Macarena Altamirano, an emotional immature girl, hardheaded, flirty, happy, innocent and very good friend, that falls in love with Byron, the role interpreted by Héctor Morales.

Mariana egressed of the University and started with the recordings, that combined with the elaboration of her thesis. After Brujas, Derderián participated in the TV serie Gatas & Tuercas. On that production, she had a minor role as Carolina "Caco" Ulloa. Derderián finished her thesis and obtained her professional title.

In 2006 she starred in Floribella, and she appeared in Los ángeles de Estela in 2009. In 2009 she was given the lead role in the Chilean version of I Dream of Jeannie.