Arsinée Khanjian (born 6 September 1958) is an Armenian-Canadian actress and producer.

In addition to her independent work and stage roles, she is regularly cast by her husband, Canadian filmmaker Atom Egoyan, in his films. She has a bachelor's degree in French and Spanish from Concordia University and a master's degree in political science from the University of Toronto.

Khanjian is a civil rights activist and was briefly detained in Armenia in 2016 while protesting human rights abuses.

Her husband, Egoyan, credits her for inspiring him to further explore his Armenian roots. She lives in Toronto with her husband and their son, Arshile.

Khanjian was a jury member for the Cinéfoundation and Short Films sections at the 2012 Cannes Film Festival.

Awards and nominations

• Gemini Award for Best Performance by an Actress in a Continuing Leading Dramatic Role for Foolish Heart (1999)
• Chlotrudis Society for Independent Film Chloe Award (2002).
• Recipient of the Queen's Golden Jubilee Medal (2002).
• Queen Zabel Award by the Eastern Prelacy of the Armenian Apostolic Church of America (2003).
• Sourp Mesrob Mashdotz Award (2003)
• Durban International Film Festival Winner for Best Actress in Ararat (2003)
• Genie Award for Best Performance by an Actress in a Leading Role in Ararat (2003).
• The Crystal Award for Creative Excellence by Women in Film and Television (2005)